The Karolinska Institute in Sweden has announced the joint Nobel Prize in Medicine for this year.
Marie E. Brinkow, Fred Remsdal and Simon Sakaguchi were awarded the prize for their discoveries of peripheral immune tolerance (a system that prevents the immune system from harming the body).
Marie E. Brinkow, 64, is a senior program manager at the Institute for Systems Biology in Seattle. Fred Remsdal, 64, is a scientific advisor at Sonoma Biotherapeutics in San Francisco, and Simon Sakaguchi, 74, is a professor at the Immunology Frontier Research Center at Osaka University in Japan.
Their research focuses on the immune system, which uses multiple overlapping mechanisms to identify and fight bacteria, viruses and other harmful agents and train key T cells to recognize these “bad guys.”
The Nobel Committee said the series began with Simone Sakaguchi’s 1995 discovery of a subtype of T cells (now known as regulatory T cells or T-regs).
Later in 2021, Marie E. Brinkow and Fred Remsdal discovered a mutation in a gene called Foxp3. This gene also plays a role in a rare autoimmune disease in humans.
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